Paper

2017

 

Kulik, M; Ochs, J; König, N; McBeth, C; Sauer-Budge, A; Sharon, A; Schmitt, R: Parallelization in Automated Stem Cell Culture. In: Procedia CIRP, 65, ISSN 2212-8271, S. 242–247, 2017

 

Roese-Koerner, B; Stappert, L, Brüstle, O: Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation Neurogenesis. 4(1):e1313647

DOI: 10.1080/23262133.2017.1313647, 2017

 

Jungverdorben, J; Till, A; Brüstle, O: Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy. In: J Mol Med (Berl), 95(7):705-718. doi: 10.1007/s00109-017-1533-5, 7 Jun 2017

 

Badenes, S M; Fernandes, T G; Miranda, C C; Pusch-Klein, A; Haupt, S; Rodrigues, C A V; Diogoa, M M; Brüstle, O; Cabrala, J M S: Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. In: J Chem Technol Biotechnol.,92(3):492-503 DOI: 10.1002/jctb.5074, 2017

 

Haubenreich, C; Lenz, M; de Boni, L; Walter, J; Schuppert, A; Koch, P; Zenke, M; Brüstle, O: Epigenetic and transcriptional alterations in human neural stem cells subjected to reprogramming and subsequent redifferentiation. In: manuscript in preparation, 2017

 

Sontag, S; Forster, M; Sere, K; Zenke, M: Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets. In: BioProtoc 7, e241, 2017

 

Sontag, S; Forster, M; Qin, J; Wanek, P; Mitzka, S; Schuler, H M; Koschmieder, S; Rose-John, S; Sere, K; Zenke, M: Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells. In: Stem Cells 35 898-908, 2017

 

 

2016

 

Kulik, M; Elanzew, A; Haupt, S; Wanek, P; Ochs, J; König, N; Zenke, M; Brüstle, O; Schmitt, R: Novel platform for fully automated generation and expansion of highly standardized iPS cells. In: Journal of Biotechnology 84, 2016, 231 Supplement , ISSN 0168-1656 , S. 33 - 34

 

Schenk, F; Brill, N; Marx, U; Hardt, D; König, N; Schmitt, R: High-speed microscopy of continuously moving cell culture vessels. In: Scientific Reports, 2016, 6, ISSN 2045-2322, S. 34038

 

Roese-Koerner, B; Stappert, L; Berger, T; Braun, N C; Veltel, M; Jungverdorben, J; Evert, B O; Peitz, M; Borghese, L; Brüstle, O: Reciprocal regulation between bifunctional miR-9/9* and its transcriptional modulator Notch in human neural stem cell self-renewal and differentiation. In: Stem Cell Reports, 2016, 7(2):207-19. doi:10.1016/j.stemcr.2016.06.008. Epub, 14 Jul 2016.

 

Falk, A; Heine, V M; Harwood, A J; Sullivan, P F; Peitz, M; Brüstle, O; Shen, S; Sun, Y M; Glover, J C; Posthuma, D; Djurovic, S: Modeling psychiatric disorders: from genomic findings to cellular phenotypes. In: Mol Psychiatry, 2016, 21(9):1167-79. doi: 10.1038/mp.2016.89. Epub, 31 Mai 2016

 

Badenes, S M; Fernandes, T G; Miranda, C C; Pusch-Klein, A; Haupt, S; Rodrigues, C A V; Diogoa, M M; Brüstle, O; Cabrala, J M S: Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. In: J Chem

Technol Biotechnol, DOI: 10.1002/jctb.5074, 2016

 

 

2015

Elanzew, A; Sommer, A; Pusch-Klein, A; Brüstle, O; Haupt, S: A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspension. In: Biotechnol J, 2015

Friedrichs, S; Malan, D; Voss, Y; Sasse, P: Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy. In: J. Clin. Med. 2015, 4(1), 102-123 (This article belongs to the Special Issue iPS Cells for Modelling and Treatment of Human Diseases

Hadenfeld, M: StemCellFactory: Eine Produktionsstraße für Stammzellen für die Wirkstoffentwicklung. In: Exzellenz NRW, Das Clustermagazin Nordrhein-Westfalen, Ausgabe 9, 2015

Lenz, M; Goetzke, R; Schenk, A; Schubert, C; Veeck, J; Hemeda, H; Koschmieder, S; Zenke, M; Schuppert, A; Wagner, W: Epigenetic biomarker to support classification into pluripotent and non-pluripotent cells. In: Scientific Reports, Volume 5, Article Number:8973, 2015

Schenk, FW; Kulik, M; Schmitt, R: Metrology-based quality and process control in automated stem cell production. In: Messtechnikbasierte Qualitätskontrolle und Prozesssteuerung in der automatisierten Stammzellproduktion. tm - Technisches Messen,  Jun Volume 82, Issue 6, 309–316, 2015

Zhang, M; Schulte, JS; Heinick, A; Piccini, I; Rao, J; Quaranta, R; Zeuschner, D; Malan, D; Kim, KP; Röpke, A; Sasse, P; Araúzo-Bravo, M; Seebohm, G; Schöler, H; Fabritz, L; Kirchhof, P; Müller, FU; Greber, B: Universal Cardiac Induction of Human Pluripotent Stem Cells in 2D and 3D formats - Implications for In-Vitro Maturation. In: Stem Cells, 2015

 

Heesen, L*; Peitz, M*; Torres-Benito, L; Hölker, I; Hupperich, K; Dobrindt, K;Jungverdorben, J; Ritzenhofen, S; Weykopf, B; Eckert, D; Hosseini-Barkooie, S M; Storbeck, M; Fusaki, N; Lonigro, R; Heller, R; Kye, M J; Brüstle, O‡; Wirth, B‡: Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals. In: Cell Mol Life Sci., 2016, 73(10):2089-104. doi:

10.1007/s00018-015-2084-y. Epub, 16 Nov 2015

 

 

2014

Frobel, J; Hemeda, H; Lenz, M; Abagnale, G; Joussen, S; Denecke, B; Saric, T; Zenke, M; Wagner, W: Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells. In: Stem Cell Reports, 3(3):414-22, 9 Sep 2014

Haupt, S: Fabrik zur Stammzellproduktion. In: Interviewbeitrag, Transkript Nr.9/2014 – 20. Jahrgang, 2014

Kadari, A; Mekala, S; Wagner, N; Malan, D; Köth, J; Doll, K; Stappert, L; Eckert, D; Peitz, M; Matthes, J; Sasse, P; Herzig, S; Brüstle, O; Ergün, S; Edenhofer, F: Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling. In: Stem Cell Rev., 13 Nov 2014

Qin, J; Sontag, S; Lin, Q; Mitzka, S; Leisten, I; Schneider, RK; Wang, X; Jauch, A; Peitz, M; Brüstle, O; Wagner, W; Zhao, RC; Zenke, M: Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells. In: Stem Cells Dev., 23(23):2875-82, 1 Dec 2014

 


2013

Koch, CM; Reck, K; Shao, K; Lin, Q; Joussen, S; Ziegler, P; Walenda, G; Drescher, W; Opalka, B; May, T; Brümmendorf, T; Zenke, M; Saric, T; Wagner, W: Pluripotent stem cells escape from senescence-associated DNA methylation changes. In: Genome Res.,23(2):248-59, Feb 2013

Lenz, M; Schuldt, BM; Müller, F-J; Schuppert, A: PhysioSpace: Relating gene expression experiments from heterogeneous sources using shared physiological processes. In: PLoS ONE, 8(10): e77627, 17 Oct 2013

Marx, U; Schenk, F; Behrens, J; Meyr, U; Wanek, P; Zang, W; Schmitt, R; Brüstle, O; Zenke, M; Klocke, F: Automatic Production of Induced Pluripotent Stem Cells. First CIRP Conference on Biomanufacturing. In: Procedia CIRP, 2013 (5):2-6

McLaren, D; Gorba, T; Marguerie de Rotrou, A; Pillai, G; Chappell, C; Stacey, A; Lingard, S; Falk, A; Smith, A; Koch, P; Brüstle, O; Vickers, R; Tinsley, J; Flanders, D; Bello, P; Craig, S: Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells. In: J Biomol Screen, 18(3):258-68, 2013

Peitz, M; Jungverdorben, J; Brüstle, O: Disease-specific iPS cell models in neuroscience. In: Curr Mol Med., 13(5):832-41, Jun 2013

Shao, K; Koch, C; Gupta, MK; Lin, Q; Lenz, M; Laufs, S; Denecke, B; Schmidt, M; Linke, M; Hennies, HC; Hescheler, J; Zenke, M; Zechner, U; Šarić, T; Wagner, W: Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles. In: Mol Ther., 21(1):240-50, Jan 2013

Willmann, CA*; Hemeda, H*; Lenz, M; Qin, J; Joussen, S; Sontag, S; Wanek, P; Denecke, B; Zenke, M; Wagner, W: To clone or not to clone? Induced pluripotent stem cells can be generated in bulk culture. In: PLoS One., 8 (5): e65324, 29 Mai 2013

HiTec Zang GmbH: Automatisierte Stammzellproduktion. In: DeviceMed., Sep 213

Rollon GmbH: Vier Linearachsen leisten saubere Arbeit. In: DeviceMed., Jun 2013


2012

Haupt, S; Grützner, J; Thier, M C; Kallweit, T; Rath, B H; Laufenberg, I; Forgber, M; Eberhardt, J; Edenhofer, F; Brüstle, O: Automated selection and harvesting of pluripotent stem cell colonies. In: Biotechnol Appl Biochem., 59(2):77-87, 2012

Haupt, S; Warnek, P; Marx, U; Zenke, M; Brüstle, O: Industrialisierung der Herstellung von iPS-Zellen. In: Laborwelt Nr.4/2012 – 13. Jahrgang.,

Hemeda, H; Wagner, W: Tracking of Replicative Senescence in Mesenchymal Stem Cells by Colony Forming Unit Assays. In: Methods Mol. Biol., 2012

Lindvall, O; Barker, R A; Brüstle, O; Isacson, O; Svendsen, C: Clinical translation of stem cells in neurodegenerative disorders. In: Cell Stem Cell, 10:151-155, 2012

Lohmann, M; Walenda, G; Hemeda, H; Joussen, S; Drescher, W; Jockenhoevel, S; Hutschenreuter, G; Zenke, M; Wagner, W: Donor age of human platelet lysate affects proliferation and differentiation of mesenchymal stem cells. In: PLoS One., 7(5):e37839, 2012

Schellenberg, A; Schellenberg, A; Stiehl, T; Horn, P; Joussen, S; Pallua, N; Ho, AD; Wagner, W: Population dynamics of mesenchymal stromal cells during culture expansion. In: Cytotherapy, 14(4):401-11, Apr 2012

Walenda, G; Hemeda, H; Schneider, RK; Merkel, R; Hoffmann, B; Wagner, W: Human platelet lysate gel provides a novel three dimensional-matrix for enhanced culture expansion of mesenchymal stromal cells. In: Tissue Eng Part C Methods, 18(12):924-34; Dec 2012