Paper

2021

 

Toledo, M. A. S., Gatz, M., Sontag, S., Gleixner, K. V., Eisenwort, G., Feldberg, K., Hamouda, A. E. I., Kluge, F., Guareschi, R., Rossetti, G., Sechi, A. S., Dufva, O. M. J., Mustjoki, S. M., Maurer, A., Schüler, H. M., Goetzke, R., Braunschweig, T., Kaiser, A., Panse, J., Jawhar, M., Reiter, A., Hilberg, F., Ettmayer, P., Wagner, W., Koschmieder, S., Brümmendorf, T. H., Valent, P., Chatain, N., and Zenke, M.: Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis.
Blood 137, 2070-2084. with Commentary by Dorrance, A. „Mast“ering drug discovery with iPSCs. Blood 137, 1993-1994. 2021

 

 

2020

 

Lampert, A., Bennett, D. L., McDermott, L. A., Neureiter, A., Eberhardt, E., Winner, B., and Zenke, M.:
Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine.
Neurobiol. Pain 8, 100055. 2020

 

Elanze, A; Nießing,B;  Langendoerfer, C; Rippel,O; Piotrowski, T; Schenk, F; Kulik, M; Peitz, M; Breitkreuz, Y; Jung, S; Wanek, P; Stappert, L; Schmitt, RH; Haupt, S; Zenke, M; König, N and Brüstle, O: The StemCellFactory: A Modular System Integration for Automated Generation and Expansion of Human Induced Pluripotent Stem Cells. In: Frontiers in Biotechnology and Biology, 2020

 

2019

 

Meents, J. E., Bressan, E., Sontag, S., Foerster, A., Hautvast, P., Rösseler, C., Hampl, M., Schüler, H., Goetzke, R., Chi Le, T. K., Kleggetveit, I. P., Le Cann, K., Kerth, C., Rush, A. M., Rogers, M., Kohl, Z., Schmelz, M., Wagner, W., Jørum, E., Namer, B., Winner, B., Zenke, M., and Lampert, A.: The role of Nav1.7 in human nociceptors: insights from human iPS cell-derived sensory neurons of erythromelalgia patients. In: Pain 160, 1327-1341. 2019

 

 

2018

 

Jung, S; Ochs, J; Kulik, M; König, N; Schmitt, R: Highly modular and generic control software for adaptive cell processing on automated production platforms. In: Procedia CIRP, 72, ISSN 1245-1250, 2018

 

 

2017

 

Kulik, M; Ochs, J; König, N; McBeth, C; Sauer-Budge, A; Sharon, A; Schmitt, R: Parallelization in Automated Stem Cell Culture. In: Procedia CIRP, 65, ISSN 2212-8271, S. 242–247, 2017

 

Roese-Koerner, B; Stappert, L, Brüstle, O: Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation Neurogenesis.  4(1):e1313647, DOI: 10.1080/23262133.2017.1313647, 2017

 

Jungverdorben, J; Till, A; Brüstle, O: Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy. In: J Mol Med (Berl), 95(7):705-718. doi: 10.1007/s00109-017-1533-5. Epub, 7 Jun 2017

 

Badenes, S M; Fernandes, T G; Miranda, C C; Pusch-Klein, A; Haupt, S; Rodrigues, C A V; Diogoa, M M; Brüstle, O; Cabrala, J M S: Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. In: J Chem Technol Biotechnol., 92(3):492-503 DOI: 10.1002/jctb.5074, 2017

 

Haubenreich, C; Lenz, M; de Boni, L; Walter, J; Schuppert, A; Koch, P; Zenke, M; Brüstle, O: Epigenetic and transcriptional alterations in human neural stem cells subjected to reprogramming and subsequent redifferentiation. In: manuscript in preparation, 2017

 

Sontag, S; Forster, M; Sere, K; Zenke, M: Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets. In: BioProtoc 7, e241, 2017

 

Sontag, S; Forster, M; Qin, J; Wanek, P; Mitzka, S; Schuler, H M; Koschmieder, S; Rose-John, S; Sere, K; Zenke, M: Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells. In: Stem Cells 35 898-908, 2017

 

 

2016

 

Kulik, M; Elanzew, A; Haupt, S; Wanek, P; Ochs, J; König, N; Zenke, M; Brüstle, O; Schmitt, R: Novel platform for fully automated generation and expansion of highly standardized iPS cells. In: Journal of Biotechnology 84, 2016, 231 Supplement , ISSN 0168-1656 , S. 33 - 34

 

Schenk, F; Brill, N; Marx, U; Hardt, D; König, N; Schmitt, R: High-speed microscopy of continuously moving cell culture vessels. In: Scientific Reports, 2016, 6, ISSN 2045-2322, S. 34038

 

Roese-Koerner, B; Stappert, L; Berger, T; Braun, N C; Veltel, M; Jungverdorben, J; Evert, B O; Peitz, M; Borghese, L; Brüstle, O: Reciprocal regulation between bifunctional miR-9/9* and its transcriptional modulator Notch in human neural stem cell self-renewal and differentiation. In: Stem Cell Reports, 2016, 7(2):207-19. doi:10.1016/j.stemcr.2016.06.008. Epub, 14 Jul 2016.

 

Falk, A; Heine, V M; Harwood, A J; Sullivan, P F; Peitz, M; Brüstle, O; Shen, S; Sun, Y M; Glover, J C; Posthuma, D; Djurovic, S: Modeling psychiatric disorders: from genomic findings to cellular phenotypes. In: Mol Psychiatry, 2016, 21(9):1167-79. doi: 10.1038/mp.2016.89. Epub, 31 Mai 2016

 

Badenes, S M; Fernandes, T G; Miranda, C C; Pusch-Klein, A; Haupt, S; Rodrigues, C A V; Diogoa, M M; Brüstle, O; Cabrala, J M S: Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. In: J Chem

Technol Biotechnol, DOI: 10.1002/jctb.5074,2016

 

 

2015

Elanzew, A; Sommer, A; Pusch-Klein, A; Brüstle, O; Haupt, S: A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspension. In: Biotechnol J, 2015

Friedrichs, S; Malan, D; Voss, Y; Sasse, P: Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy. In: J. Clin. Med., 4(1), 102-123 (This article belongs to the Special Issue iPS Cells for Modelling and Treatment of Human Diseases, 2015

Hadenfeld, M: StemCellFactory: Eine Produktionsstraße für Stammzellen für die Wirkstoffentwicklung. In: Exzellenz NRW, Das Clustermagazin Nordrhein-Westfalen, Ausgabe 9, 2015

Lenz, M; Goetzke, R; Schenk, A; Schubert, C; Veeck, J; Hemeda, H; Koschmieder, S; Zenke, M; Schuppert, A; Wagner, W: Epigenetic biomarker to support classification into pluripotent and non-pluripotent cells. In: Scientific Reports, Volume 5, Article Number:8973, 2015

Schenk, FW; Kulik, M; Schmitt, R: Metrology-based quality and process control in automated stem cell production. In: Messtechnikbasierte Qualitätskontrolle und Prozesssteuerung in der automatisierten Stammzellproduktion. tm - Technisches Messen,  Jun Volume 82, Issue 6, 309–316, 2015

Zhang, M; Schulte, JS; Heinick, A; Piccini, I; Rao, J; Quaranta, R; Zeuschner, D; Malan, D; Kim, KP; Röpke, A; Sasse, P; Araúzo-Bravo, M; Seebohm, G; Schöler, H; Fabritz, L; Kirchhof, P; Müller, FU; Greber, B: Universal Cardiac Induction of Human Pluripotent Stem Cells in 2D and 3D formats - Implications for In-Vitro Maturation. In: Stem Cells, 2015

 

Heesen, L*; Peitz, M*; Torres-Benito, L; Hölker, I; Hupperich, K; Dobrindt, K;Jungverdorben, J; Ritzenhofen, S; Weykopf, B; Eckert, D; Hosseini-Barkooie, S M; Storbeck, M; Fusaki, N; Lonigro, R; Heller, R; Kye, M J; Brüstle, O‡; Wirth, B‡: Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals. In: Cell Mol Life Sci., 2016, 73(10):2089-104. doi:

10.1007/s00018-015-2084-y. Epub, 16 Nov 2015

 

 

2014

Frobel, J; Hemeda, H; Lenz, M; Abagnale, G; Joussen, S; Denecke, B; Saric, T; Zenke, M; Wagner, W: Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells. In: Stem Cell Reports, 3(3):414-22, 9 Sep 2014

Haupt, S: Fabrik zur Stammzellproduktion. In: Interviewbeitrag, Transkript Nr.9/2014 – 20. Jahrgang, 2014

Kadari, A; Mekala, S; Wagner, N; Malan, D; Köth, J; Doll, K; Stappert, L; Eckert, D; Peitz, M; Matthes, J; Sasse, P; Herzig, S; Brüstle, O; Ergün, S; Edenhofer, F: Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling. In: Stem Cell Rev., 13 Nov 2014

Qin, J; Sontag, S; Lin, Q; Mitzka, S; Leisten, I; Schneider, RK; Wang, X; Jauch, A; Peitz, M; Brüstle, O; Wagner, W; Zhao, RC; Zenke, M: Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells. In: Stem Cells Dev., 23(23):2875-82, 1 Dez 2014

 


2013

Koch, CM; Reck, K; Shao, K; Lin, Q; Joussen, S; Ziegler, P; Walenda, G; Drescher, W; Opalka, B; May, T; Brümmendorf, T; Zenke, M; Saric, T; Wagner, W: Pluripotent stem cells escape from senescence-associated DNA methylation changes. In: Genome Res.,23(2):248-59, Feb 2013

Lenz, M; Schuldt, BM; Müller, F-J; Schuppert, A: PhysioSpace: Relating gene expression experiments from heterogeneous sources using shared physiological processes. In: PLoS ONE, 8(10): e77627, 17 Okt 2013

Marx, U; Schenk, F; Behrens, J; Meyr, U; Wanek, P; Zang, W; Schmitt, R; Brüstle, O; Zenke, M; Klocke, F: Automatic Production of Induced Pluripotent Stem Cells. First CIRP Conference on Biomanufacturing. In: Procedia CIRP, 2013 (5):2-6

McLaren, D; Gorba, T; Marguerie de Rotrou, A; Pillai, G; Chappell, C; Stacey, A; Lingard, S; Falk, A; Smith, A; Koch, P; Brüstle, O; Vickers, R; Tinsley, J; Flanders, D; Bello, P; Craig, S: Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells. In: J Biomol Screen, 18(3):258-68, 2013

Peitz, M; Jungverdorben, J; Brüstle, O: Disease-specific iPS cell models in neuroscience. In: Curr Mol Med., 13(5):832-41, Jun 2013

Shao, K; Koch, C; Gupta, MK; Lin, Q; Lenz, M; Laufs, S; Denecke, B; Schmidt, M; Linke, M; Hennies, HC; Hescheler, J; Zenke, M; Zechner, U; Šarić, T; Wagner, W: Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles. In: Mol Ther., 21(1):240-50, Jan 2013

Willmann, CA*; Hemeda, H*; Lenz, M; Qin, J; Joussen, S; Sontag, S; Wanek, P; Denecke, B; Zenke, M; Wagner, W: To clone or not to clone? Induced pluripotent stem cells can be generated in bulk culture. In: PLoS One., 8 (5): e65324, 29 Mai 2013

HiTec Zang GmbH: Automatisierte Stammzellproduktion. In: DeviceMed., Sep 213

Rollon GmbH: Vier Linearachsen leisten saubere Arbeit. In: DeviceMed., Jun 2013


2012

Haupt, S; Grützner, J; Thier, M C; Kallweit, T; Rath, B H; Laufenberg, I; Forgber, M; Eberhardt, J; Edenhofer, F; Brüstle, O: Automated selection and harvesting of pluripotent stem cell colonies. In: Biotechnol Appl Biochem., 59(2):77-87, 2012

Haupt, S; Warnek, P; Marx, U; Zenke, M; Brüstle, O: Industrialisierung der Herstellung von iPS-Zellen. In: Laborwelt Nr.4/2012 – 13. Jahrgang.,

Hemeda, H; Wagner, W: Tracking of Replicative Senescence in Mesenchymal Stem Cells by Colony Forming Unit Assays. In: Methods Mol. Biol., 2012

Lindvall, O; Barker, R A; Brüstle, O; Isacson, O; Svendsen, C: Clinical translation of stem cells in neurodegenerative disorders. In: Cell Stem Cell, 10:151-155, 2012

Lohmann, M; Walenda, G; Hemeda, H; Joussen, S; Drescher, W; Jockenhoevel, S; Hutschenreuter, G; Zenke, M; Wagner, W: Donor age of human platelet lysate affects proliferation and differentiation of mesenchymal stem cells. In: PLoS One., 7(5):e37839, 2012

Schellenberg, A; Schellenberg, A; Stiehl, T; Horn, P; Joussen, S; Pallua, N; Ho, AD; Wagner, W: Population dynamics of mesenchymal stromal cells during culture expansion. In: Cytotherapy, 14(4):401-11, Apr 2012

Walenda, G; Hemeda, H; Schneider, RK; Merkel, R; Hoffmann, B; Wagner, W: Human platelet lysate gel provides a novel three dimensional-matrix for enhanced culture expansion of mesenchymal stromal cells. In: Tissue Eng Part C Methods, 18(12):924-34; Dez 2012